CAN04 is a first-in-class fully humanized monoclonal antibody targeting IL1RAP blocking IL-1 alpha and beta signaling and triggering antibody dependent cellular cytotoxicity. Methods: The primary objective was to assess safety and tolerability of weekly CAN04 in order to define the Recommended Phase 2 …
Targeted antibodies are a type of immunotherapy that can disrupt cancer cell Monoclonal Antibodies, Antibody-Drug Conjugates, and Bispecific Antibodies.
Thereby, CAN04 can counteract the contribution of the IL-1 system to the immune suppressive tumor microenvironment and development of resistance to chemotherapy. CAN04 is investigated in two clinical trials. CAN04, an antibody targeting interleukin 1 receptor accessory protein (IL1RAP), is currently being investigated for treatment of non-small cell lung cancer (NSCLC) and pancreatic cancer (PDAC) in phase IIa clinical development. The CAN04 antibody is targeted against IL1RAP, found in a number of cancer forms. The first sites in the phase I/IIa clinical trial CANFOUR have been initiated and patient recruitment is ongoing. According to the protocol, patients are recruited in groups of three.
According to the protocol, patients are recruited in groups of three. Cantargia’s antibody CAN04 binds IL1RAP with high affinity and functions through both Antibody Dependent Cellular Cytotoxicity and blockade of interleukin 1 signaling. CAN04 is investigated in phase IIa clinical development for non-small cell lung cancer (NSCLC) and pancreatic cancer (PDAC). Tumor samples from 15 patients 2019-06-02 2019-11-15 The antibody CAN04 binds IL1RAP with high affinity and functions through both Antibody-Dependent Cellular Cytotoxicity (ADCC) and blockade of IL-1 signaling. A new phase Ib clinical trial CAN04, an antibody targeting interleukin 1 receptor accessory protein (IL1RAP), is currently being investigated for treatment of non-small cell lung cancer (NSCLC) and pancreatic cancer (PDAC) in phase IIa clinical development in Europe. The antibody CAN04 binds strongly to the target IL1RAP and functions both though ADCC as well as blocking IL-1α and IL-1β signaling.
Cantargia AB (publ) and Patheon Biologics B.V. (part of ThermoFischer Scientific) have signed an agreement regarding future production of the antibody CAN04 (nidanilimab). CAN04 is currently in phase IIa clinical development for non-small cell lung cancer and pancreatic cancer. Hereby, Cantargia secures additional production capacity for future clinical trials.
CAN04, the company's patented antibody treatment, has a dual mechanism of action. CAN04 fights cancer by activating the immune system and The antibody CAN04 binds strongly to the target IL1RAP and functions both though ADCC as well as blocking IL-1α and IL-1β signaling. Thereby, CAN04 can counteract the contribution of the IL-1 system to the immune suppressive tumor microenvironment and development of resistance to chemotherapy.
future production of the CAN04 antibody. • In May 2019, Cantargia announced new preclinical results showing positive effects when the CAN04 antibody is combined with various platinum-based chemotherapies. • New phase I clinical data on Cantargia´s antibody CAN04 (nidanilimab) were presented June 2 in an oral session at
Cantargia’s antibody CAN04 binds IL1RAP with high affinity and functions through both Antibody Dependent Cellular Cytotoxicity and blockade of interleukin 1 signaling. CAN04 is investigated in phase IIa clinical development for non-small cell lung cancer (NSCLC) and pancreatic cancer (PDAC). Tumor samples from 15 patients 2019-06-02 2019-11-15 The antibody CAN04 binds IL1RAP with high affinity and functions through both Antibody-Dependent Cellular Cytotoxicity (ADCC) and blockade of IL-1 signaling. A new phase Ib clinical trial CAN04, an antibody targeting interleukin 1 receptor accessory protein (IL1RAP), is currently being investigated for treatment of non-small cell lung cancer (NSCLC) and pancreatic cancer (PDAC) in phase IIa clinical development in Europe. The antibody CAN04 binds strongly to the target IL1RAP and functions both though ADCC as well as blocking IL-1α and IL-1β signaling. Thereby, CAN04 can counteract the contribution of the IL-1 system to the immune suppressive tumor microenvironment and development of resistance to chemotherapy. CAN04 is investigated in two clinical trials.
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0% ORR/ 43% CBR for the dose-escalation monotherapy The 9H10 monoclonal antibody reacts with mouse CTLA-4 (cytotoxic T lymphocyte antigen-4) also known as CD152. CTLA-4 is a 33 kDa cell surface receptor Recombinant anti-Human CCR4 (CD194) antibody. Clone KW-0761 ( Mogamulizumab).
Cantargia develops antibody based therapy against the target IL1RAP. The lead candidate CAN04 is for treatment of solid tumors and hematoligacal cancers,
Antikroppen CAN04 binder IL1RAP med hög affinititet och fungerar både genom blockad av IL-1-signalering samt s k Antibody-Dependent
"Ig knock-in mice producing anti-carbohydrate antibodies: breakthrough of B cells producing low affinity anti-self antibodies". Journal of CAN-04-3675.
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Mar 1, 2021 The main project, the antibody CAN04, is being studied clinically as combination therapy with chemotherapy or immune therapy with a primary
Cantargia’s antibody CAN04 binds IL1RAP with high affinity and functions through both Antibody Dependent Cellular Cytotoxicity and blockade of interleukin 1 signaling. CAN04 is investigated in phase IIa clinical development for non-small cell lung cancer (NSCLC) and pancreatic cancer (PDAC). Tumor samples from 15 patients The antibody CAN04 binds strongly to the target IL1RAP and functions both though ADCC as well as blocking IL-1α and IL-1β signaling. Thereby, CAN04 can counteract the contribution of the IL-1 system to the immune suppressive tumor microenvironment and development of resistance to chemotherapy.